18F-Fluciclovine (18F-FACBC) PET/MRI Findings in Tumefactive Demyelinating Lesion: A Case Report.

Authors

Akihiko Sakata, Shigeki Takada, Yasuhide Takeuchi, Yoshiki Arakawa, Yuji Nakamoto

Published in

Clinical nuclear medicine. Volume 51. Issue 9. Pages e779-e781. Sep 01, 2026. Epub Mar 02, 2026.

Abstract

A 28-year-old man presented with acute onset dysarthria and right facial droop. MRI revealed a horseshoe-shaped mass in the left frontal lobe, and tumefactive demyelinating lesion (TDL) was suspected. Despite steroid pulse therapy, follow-up imaging demonstrated lesion enlargement, raising concern for malignancy. 18F-Fluciclovine (18F-FACBC) PET/MRI showed moderate tracer accumulation. Surgical resection was performed, and the diagnosis of TDL was confirmed. This represents the first reported case of TDL evaluated with 18F-Fluciclovine PET imaging. The discordance between moderate tracer uptake and rapid lesion growth may be useful for differentiating TDL from glioma.

PMID:
42546266
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.