Authors
Brin E Freund, Venkateshwaran Vijayanarasimhan, Adrian Safa, Justyna Ekert, Filippo Emmanuele Colella, Cady Block, David Sabsevitz, Carlos Perez-Vega, Erik H Middlebrooks, Seyed M Mirsattari, Richard Byrne, William O Tatum
Published in
Journal of neurosurgery. Case lessons. Volume 12. Issue 5. Aug 03, 2026. Epub Aug 03, 2026.
Abstract
The authors aimed to evaluate the feasibility/safety of stereo-electroencephalography (SEEG) and SEEG-guided radiofrequency thermocoagulation (RFTC) in patients with drug-resistant epilepsy previously implanted with neuromodulation devices, using a retrospective cohort design evaluating patients treated at the Mayo Clinic Florida Epilepsy Center.
Nine patients (mean age 36.3 ± 10.9 years, 33% female) with prior implantation of neuromodulation devices were included. A vagus nerve stimulator was present in 8 of 9 patients, and 4 patients had undergone previous intracranial neuromodulation. Five patients underwent SEEG-RFTC. The mean SEEG monitoring duration was 6.5 ± 2.9 days. No intraoperative or procedural complications occurred, including hardware-related issues. No permanent or significant neurological/cognitive deficits occurred. One patient experienced transient postoperative neurological symptoms attributed to perilesional edema. Seizure reduction ranged from 50% to 75% following SEEG-RFTC.
SEEG and SEEG-RFTC are feasible in patients who have implanted neuromodulation devices, including intracranial implants. These procedures may be performed without interference with existing hardware and provide meaningful seizure reduction in highly refractory populations. Further studies with larger cohorts and longer follow-up are needed to better define efficacy and patient selection. https://thejns.org/doi/10.3171/CASE26376.
PMID:
42546343
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.
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