Secondary Cytoreductive Surgery ± Hyperthermic Intraperitoneal Chemotherapy for Recurrent Colorectal Cancer Peritoneal Metastases.

Authors

Kailey M Oppat, Frances J Bennett, Sameer H Patel, Mustafa Raoof, Joel M Baumgartner, Harveshp D Mogal, Laura A Lambert, Daniel E Abbott, Jonathan B Greer, Travis E Grotz, Keith F Fournier, Sean P Dineen, Benjamin Powers, Mohammad Y Zaidi, Joshua H Winer, Maria C Russell, Charles A Staley, Jordan M Cloyd, Shishir K Maithel, Seth J Concors

Published in

Annals of surgical oncology. Aug 03, 2026. Epub Aug 03, 2026.

Abstract

Most patients who have colorectal cancer peritoneal metastases (CRC-PM) treated with cytoreductive surgery ± hyperthermic intraperitoneal chemotherapy (CRS±HIPEC) experience recurrence within 1 year. This study assessed the safety and oncologic value of secondary CRS±HIPEC for patients with CRC-PM.
A multi-institutional database of patients treated for CRC-PM (2000-2024) was reviewed. Patients who underwent curative-intent initial CRS±HIPEC alone were compared with those who underwent secondary CRS±HIPEC for recurrent disease. Patients who received more than two procedures were excluded. The primary objective was to evaluate the safety of secondary CRS±HIPEC for CRC-PM as measured by perioperative outcomes. The secondary objective was to examine the association between overall survival (OS) and secondary CRS±HIPEC.
The study included 136 patients, 17 of whom underwent secondary CRS±HIPEC. There was no difference in postoperative complications between secondary and initial CRS±HIPEC. When OS was defined from the date of the index operation, secondary CRS±HIPEC was associated with improved OS versus initial CRS±HIPEC alone (51.0 months [95% confidence interval {CI}, 39.8-62.2 months] vs. 24.0 months [95 % CI, 19.4-28.6) months]). To assess the value of secondary CRS±HIPEC, OS was compared from the date of the second procedure for the secondary cohort. Overall survival measured after secondary CRS±HIPEC was similar to that after initial CRS±HIPEC (27.0 months [95 % CI, 17.3-36.7 months] vs. 24.0 months [95 % CI, 19.4-28.6 months]). Among the patients with recurrence after their index CRS±HIPEC, secondary CRS±HIPEC remained associated with better OS than that of those who received only one procedure (27.0 months [95 % CI, 17.3-36.7 months] vs. 12.0 months [95 % CI, 9.2-14.8 months]).
Secondary CRS±HIPEC should be considered for well-selected patients with CRC-PM recurrence.

PMID:
42547752
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.

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