Towards a biologically informed description of multiple sclerosis disease course - a roadmap for transition.

Authors

Alan J Thompson, Fred D Lublin, Lindsay Rechtman, James Quinn, Maria Pia Amato, Bruce Bebo, Peter A Calabresi, Julie Fiol, Marcia Finlayson, Annie Hawton, Tanja Kuhlmann, Ruth Ann Marrie, Marcello Moccia, Xavier Montalban, Michael Panzara, Kathy Smith, Maria Pia Sormani, Jon Strum, Barbara G Vickrey, Timothy Coetzee, 2025 International Advisory Committee on Clinical Trials in Multiple Sclerosis

Published in

Nature reviews. Neurology. Aug 03, 2026. Epub Aug 03, 2026.

Abstract

Contemporary management of multiple sclerosis is based on the clinical course descriptors of relapsing-remitting, secondary progressive and primary progressive. However, recognition is growing in the field that these clinical course descriptors do not capture the full disease spectrum of multiple sclerosis or reflect the underlying biological mechanisms of disease, and that biologically informed course descriptors are needed. In this Roadmap, participants in an International Advisory Committee on Clinical Trials in Multiple Sclerosis workshop discuss the problems with the existing course descriptors, highlight considerations for developing new course descriptors and propose a roadmap for transitioning towards a more dynamic, biologically informed description of the multiple sclerosis disease course.

PMID:
42547548
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.

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