Authors
Xinru Shen, Ying Zhang, Mengyan Shan, Yiqing Kou, Xintao Jia, Mengru Yang, Changxiang Yu, Jingbai Li, Pan Guo, Jiawei Li, Zhidong Liu
Published in
Biomaterials research. Volume 30. Pages 0398. Epub Aug 03, 2026.
Abstract
Triple-negative breast cancer (TNBC) presents formidable treatment barriers due to dysfunctional vasculature and an immunosuppressive microenvironment. To address these challenges, we engineered a bioinspired near-infrared (NIR)-responsive copper-polyphenol nanoplatform, SCP, to implement a NIR-triggered "bridge-and-attack" therapeutic strategy. This nanoassembly was constructed through the coordination of salvianolic acid B (SAB) with copper ions and further stabilized by a polydopamine (PDA) shell. Upon NIR irradiation, SAB and Cu2+ were co-released from SCP, enabling simultaneous vascular remodeling and tumor cell killing. The released SAB promoted vascular normalization, increasing pericyte coverage to 51.6% and alleviating tumor hypoxia, thereby facilitating intratumoral penetration and immune-cell infiltration. Meanwhile, released Cu2+, together with PDA-mediated photothermal activation, induced cuproptosis and immunogenic cell death (ICD). This combined remodeling of the tumor microenvironment enhanced CD8+ T cell infiltration and achieved a tumor inhibition rate of 88.5% in 4T1 tumor-bearing mice with favorable systemic biosafety. Overall, this interfacial nanomaterial design integrates vascular normalization, photothermal-enhanced cuproptosis, and immunotherapy, providing a promising materials-based strategy for TNBC treatment.
PMID:
42548927
Bibliographic data and abstract were imported from PubMed on 04 Aug 2026.
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