Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker Cohorts.

Authors

Junyun Wang, Yuzhen Feng, Junxiu Zhao, Jing Dai, Fangda Peng, Yazhen He, Xiao Yu, Xiaomei Kong, Yiwei Shi, Jisheng Nie, Chunguang Ding

Published in

Journal of occupational and environmental medicine. Aug 04, 2026. Epub Aug 04, 2026.

Abstract

To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts.
We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and external (n=221) cohorts comprising pneumoconiosis, dust-exposed noncase, and nonexposed healthy control participants. Candidate lipids were selected by covariate-adjusted screening and LASSO, then tested with clinical covariates.
A five-lipid panel was retained. In the external cohort, Firth logistic regression achieved AUC 0.983, sensitivity 0.923, and specificity 0.955. Cytokine-lipid correlations supported inflammatory plausibility.
This panel may support occupational triage for confirmatory imaging, pending prospective multicenter validation.

PMID:
42551022
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.

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