The role of ceramides in the pathophysiology of diabetic retinopathy: Mechanisms and Implications for therapeutic strategies.

Authors

Xiaoji Niu, Yiwei Huang, Chao Sun, Yan Huo, Kanghua Fu, Shishuang Yu, Tianyuan Wang, Jiajia Liu, Weirong Pu, Jinping Hu, Liman Ren

Published in

Diabetes & vascular disease research. Volume 23. Issue 4. Pages 14791641261474007. Epub Aug 04, 2026.

Abstract

Diabetic retinopathy (DR) is a leading cause of vision impairment among individuals with diabetes, driven by microvascular damage and retinal degeneration. Recent evidence implicates ceramides-bioactive sphingolipids-as critical mediators in DR pathogenesis. These lipids influence critical cellular processes, including apoptosis, inflammation, and oxidative stress. Emerging data suggests that ceramide accumulation exacerbates retinal neurodegeneration in DR by modulating key molecular pathways. This review synthesizes current knowledge on the role of ceramides in DR development and progression, examines the factors influencing their activity, and explores the therapeutic potential of targeting ceramide metabolism. By integrating recent findings, this article aims to provide insights for future research and clinical strategies in DR management.

PMID:
42550914
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.

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