Authors
Isabel Malta Carvalho, Tânia Gago, Luís Relvas, Margarida Portugal, Jesus Cadilla, Bruno Peixe
Published in
GE Portuguese journal of gastroenterology. Volume 33. Issue 1. Pages 566-571. Epub Jun 18, 2026.
Abstract
Verrucous carcinoma of the esophagus is an extremely rare malignancy, described as a well-differentiated variant of esophageal squamous cell carcinoma, typically exhibiting exophytic/verrucous growth and intraluminal involvement that is often rich in inflammation and hyperkeratosis, which hampers histologic diagnosis and consequently delays treatment. We report the case of a 58-year-old woman with progressive dysphagia and a circumferential, verrucous esophageal lesion, without histologic confirmation despite multiple biopsies and endoscopic resections, showing only focal p16 positivity. After further evaluation with CT, endoscopic ultrasound, and FDG-PET/CT, a presumptive diagnosis of locally advanced verrucous carcinoma of the esophagus was assumed, and palliative chemotherapy was initiated, followed by a sustained endoscopic and radiologic response. This case highlights the importance of multidisciplinary discussion when verrucous carcinoma of the esophagus is suspected and the unexpected, sustained response despite unresectability.
PMID:
42553956
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.
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