Biomolecular condensates in fungi: mechanisms and regulatory roles.

Authors

Emma E Blackburn, Xiaorong Lin

Published in

Microbiology and molecular biology reviews : MMBR. Pages e0001226. Aug 05, 2026. Epub Aug 05, 2026.

Abstract

SUMMARYLiquid-liquid phase separation (LLPS) drives the formation of biomolecular condensates, a conserved phenomenon across eukaryotes. This process governs diverse cellular programs, from stress response and morphogenesis to disease pathology. Over the past two decades, the regulatory impact of biomolecular condensates in fungal biology has become increasingly recognized. In this review, we examine the fundamental molecular mechanisms driving LLPS, evaluate the current evidence for LLPS in macromolecular organization and cellular regulation in fungi, and outline the tools employed to study this phenomenon. Lastly, we highlight the challenges of bridging the gap between the in vitro behavior of biomolecular condensates and their complex regulatory functions in vivo within fungal biology.

PMID:
42554499
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.

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