Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

Authors

Javed Butler, Francesco Fioretti, Stefan D Anker, Muhammad Shahzeb Khan, Catherine N Marti, Ambarish Pandey, Mikael Petersson, Jennifer Linge

Published in

JACC. Heart failure. Pages 103242. Aug 03, 2026. Epub Aug 03, 2026.

Abstract

Metabolic and musculoskeletal abnormalities in patients with heart failure (HF) may not be fully captured by body mass index.
Body composition was studied in participants with HF and matched control subjects in the UK Biobank Imaging Study, and findings were compared among those with HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction.
Participants with HF and available ejection fraction (n = 185) were matched 1:5 to age-, sex-, and body mass index-matched control subjects (n = 925). Whole-body magnetic resonance-quantified visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue, liver fat, thigh fat-free muscle volume (MV), and muscle fat infiltration (MFI) were assessed. Personalized z-scores adjusted for sex and body size were derived. Adverse muscle composition (AMC) was defined as low MV z-score and high MFI. Dual-energy x-ray absorptiometry was used to measure total fat and appendicular lean mass.
Compared with control subjects, HF participants had higher VAT (z-score = 0.46 ± 1.1 vs 0.07 ± 1.0; P < 0.001), MFI (8.4 ± 2.3% vs 7.6 ± 2.0%; P < 0.001), and AMC (36% vs 17%; P < 0.001) and lower MV (z-score = -0.7 ± 1.0 vs -0.1 ± 0.9; P < 0.001). Despite the muscle derangements identified by magnetic resonance imaging assessment, the prevalence of sarcopenia diagnosed using combined grip strength and dual-energy x-ray absorptiometry-derived lean mass parameters varied considerably depending on the criteria applied. Among HF subtypes, HF with mildly reduced ejection fraction showed the highest VAT and lowest MV, HF with preserved ejection fraction had greater fat and MFI, and HF with reduced ejection fraction had the greatest prevalence of AMC and the weakest grip strength.
Participants with HF showed higher VAT and adverse muscle changes, with weaker grip strength. Sarcopenia prevalence varied substantially across definitions, reflecting substantial variability and discrepancies among current sarcopenia definitions and criteria. Traditional anthropometric indexes underestimate the burden of body composition derangements in HF.

PMID:
42554540
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.

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