Novel Direct Transcatheter Mitral Annuloplasty System: Preclinical Feasibility Study.

Authors

Wanjiao Chen, Yuliang Long, Wei Li, Xiaochun Zhang, Lei Zhang, Daxin Zhou, Wenzhi Pan, Junbo Ge

Published in

JACC. Asia. Volume 6. Issue 8 Pt 1. Pages 1601-1605.

Abstract

This study evaluated the novel L-Clip transcatheter mitral annuloplasty device in 18 porcine models, demonstrating its efficacy and safety. The device achieved 100% procedural success. Implantation times were a median of 28.4 minutes (22.7-34.1) for the first clip and 39.7 minutes (31.2-48.2) for the second. Significant immediate reductions were observed: annular area decreased 26% (from 13.4 cm² [11.2-15.6] to 9.9 cm² [7.5-12.3], P < 0.001), anteroposterior diameter decreased 31% (from 3.6 cm [3.2-4.0] to 2.5 cm [2.0-3.0], P < 0.001), and intercommissural distance decreased 17% (from 4.1 cm [3.8-4.4] to 3.4 cm [3.1-3.7], P < 0.001). Crucially, no mortality, valve damage, device displacement, embolism, or other serious adverse events occurred. The L-Clip system offers a user-friendly approach, achieving substantial annular reduction with an excellent safety profile in this model. These promising results support its potential as a minimally invasive alternative for functional mitral regurgitation, warranting further clinical investigation.

PMID:
42554399
Bibliographic data and abstract were imported from PubMed on 05 Aug 2026.

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