Authors
Geraldine Vitry, Jerry Angdisen, Pauline Arriaga, Shawn Irgen-Gioro, Megan A Sawant, Daniel C Vuong, Peter Ilhardt, Jacques Fehr, Bartosz Cwikla, Brian Ponnaiya, Jamie L Inman, Jian-Hua Mao, Antoine M Snijders, Shazia Hamid, David Caballero-Lima, Guy Garty, Karyn Apfeldorf, Evagelia C Laiakis
Published in
PloS one. Volume 21. Issue 8. Pages e0354734. Epub Aug 05, 2026.
Abstract
Exposure to ionizing radiation poses major health risks across medical, occupational, and spaceflight settings, driving the need for rapid, non-invasive biodosimetry tools. As the body's most accessible organ and the most frequent site of radiation injury, the skin represents a promising interface for monitoring exposure. Using colonized human skin equivalents (coHSE; 0 Gy n = 8, 1 Gy n = 6, 4 Gy n = 6) and mice (n = 6/group) models, we performed multi-omic profiling, integrating metabolomics, lipidomics, and metagenomics, on skin swab samples collected after exposure to 0, 1, or 4 Gy of x-rays. We identified two distinct metabolite panels: one discriminating irradiated from non-irradiated skin, and another distinguishing dose-specific response. These panels included conserved radiation-responsive metabolites (e.g., uric acid, xanthine, taurine) and skin-specific markers associated with barrier integrity (e.g., proline, arginine). Diacylglycerol network enrichment and shifts in radioprotective microbial taxa, including Lachnospiraceae and Lactobacillales, further supported a repair-driven molecular response. These data support the feasibility of skin swab signatures for non-invasive exposure classification, providing a molecular and microbial framework for skin based monitoring measure development and motivating validation in human cohorts for real-world biodosimetry.
PMID:
42555569
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.
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