Authors
Takuya Shiraishi, Yutaro Shimizu, Chika Katayama, Yuta Shibasaki, Chika Komine, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Ken Shirabe, Hiroshi Saeki
Published in
Surgery today. Aug 06, 2026. Epub Aug 06, 2026.
Abstract
Oral frailty may increase surgical risk; however, its association with postoperative infections in patients with colorectal cancer remains unclear. We evaluated whether preoperative oral frailty, assessed using the Oral Frailty Index-8 (OFI-8), could predict 30-day postoperative infectious complications.
We retrospectively reviewed patients who underwent colorectal cancer surgery between April 2022 and December 2024 at our institution. Before surgery, patients completed the OFI-8 and Mini Nutritional Assessment Short-Form, which were verified by the nursing staff. A high oral frailty risk was defined as an OFI-8 score ≥ 4. Clinicopathological variables and infectious complications were compared between the groups. Logistic regression was used to identify the factors associated with complications.
Among the 140 patients, those with OFI-8 ≥ 4 were older and had more polypharmacy, larger tumors, and a poorer renal function. Eighteen patients developed infectious complications. Age ≥ 75 years, rectal cancer, OFI-8 ≥ 4, and pathological T4 stage were identified as predictors of infectious complications. Multivariate analyses confirmed that OFI-8 ≥ 4 and rectal cancer were independent risk factors. Infectious complications were associated with prolonged hospitalization.
OFI-8 is a simple outpatient screening tool for identifying patients at high risk of infectious complications following colorectal cancer surgery. Targeted OFI-8-guided perioperative risk interventions may improve the outcomes and reduce the healthcare burden.
PMID:
42560536
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.
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