Application of transrectal three-dimensional ultrasound for sub-staging of locally advanced rectal cancer at stage T3.

Authors

Xiaohong Deng, Weiqin Huang, Wenting Xie, Xiaohui Ke, Shen Guan, Yaoqin Wang, Lina Tang

Published in

Abdominal radiology (New York). Aug 06, 2026. Epub Aug 06, 2026.

Abstract

To evaluate the value of transrectal three-dimensional ultrasound (3D-TRUS) in the T3 sub-staging of locally advanced rectal cancer.
A retrospective analysis was conducted on patients with non-metastatic T3 stage rectal cancer who were diagnosed and treated at Fujian Cancer Hospital from December 2021 to December 2025. Preoperative T3 sub-staging data obtained via 3D-TRUS were compared with those obtained from the current standard magnetic resonance imaging (MRI) findings. The sensitivity, specificity, and Kappa statistic of the ultrasound method were evaluated.
A total of 174 patients were included, achieving a lesion detection rate of 100%. 3D-TRUS demonstrated substantial agreement with magnetic resonance imaging (MRI) for determining T3 sub-staging (Kappa = 0.734, p < 0.001), with a specificity at 90.4%, a sensitivity at 83.3%, and an overall accuracy at 73.7%.
3D-TRUS demonstrates high accuracy in T3 sub-staging of locally advanced rectal cancer and offers a high-resolution, practical option for the clinical management of locally advanced rectal cancer.

PMID:
42560491
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.

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