Authors
Kamyar Moradi, Roham Hadidchi, Amyn Majbri, Timothy M Hughes, Hanzhang Lu, Yuxin Zhu, Soheil Mohammadi, Sara Momtazmanesh, Pratik Mukherjee, Muhammad Abdullah, Eleanor Simonsick, Jennifer A Schrack, Marcus D Goncalves, Josef Coresh, Marilyn Albert, Shadpour Demehri
Published in
Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 8. Pages e71622.
Abstract
Skeletal muscle loss is associated with cognitive decline, but whether neuroimaging-derived muscle characteristics predict incident dementia remains unclear.
We evaluated associations of deep learning-derived temporalis muscle (TM) cross-sectional area (CSA) and radiomic texture features from baseline T1-weighted magnetic resonance imaging (MRI) with incident dementia in dementia-free participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (n = 750) and the Atherosclerosis Risk in Communities (ARIC) study (n = 532). TM was segmented using a convolutional neural network trained in ADNI and externally validated in ARIC. Radiomic features were reduced using least absolute shrinkage and selection operator-penalized Cox models to generate a composite score. Multivariable Cox regression adjusted for demographics, apolipoprotein E ε4, baseline cognition, body mass index, and physical performance.
Higher TM radiomic scores were associated with increased dementia risk in ADNI (hazard ratio per SD, 1.32) and ARIC (1.64). Smaller TM CSA predicted dementia in ADNI but not ARIC.
TM texture patterns from routine brain MRI are associated with dementia risk, supporting TM phenotyping as a scalable marker of systemic biological vulnerability.
PMID:
42559821
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.
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