Pulcherriminic acid as an antibiofilm effector: expanding Bacillus functionality against yeast biofilms.

Authors

Ramya Srinivasan, Tamil Selvam Saravanan, Soham Utpat, Moshe Shemesh, Satish Kumar Rajasekharan

Published in

Journal of bacteriology. Pages e0018426. Aug 06, 2026. Epub Aug 06, 2026.

Abstract

Pathogenic and persistent biofilms are a major challenge in medicine and industry, acting as resilient microbial communities that resist antibiotics and cause persistent infections. In this review, we discuss pulcherriminic acid, a promising iron-chelating molecule produced by antagonistic Bacillus subtilis as a natural weapon against persistent biofilms, particularly those formed by pathogens such as Candida albicans. Drawing on recent research, we explore pulcherriminic acid biosynthesis, its native mechanism of depriving fungi of essential iron to disrupt their growth and virulence, and innovative methods to enhance its production through metabolic engineering. We also highlight its potential applications, from fighting infections to serving as a biocontrol agent in agriculture and even as a natural preservative in food. By harnessing this Bacillus-derived metabolite, we suggest sustainable ideas for tackling antibiotic resistance and persistent biofilm-related problems.

PMID:
42560306
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.