Authors
Y Hang, Q Jin, F Tang, R L Ge
Published in
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. Volume 49. Issue 8. Pages 908-912. Aug 12, 2026.
Abstract
Preserved ratio impaired spirometry (PRISm) is an intermediate phenotype between normal lung function and chronic obstructive pulmonary disease (COPD), and it carries a high risk of progressing to COPD. Due to unique factors such as hypobaric hypoxia, the detection rate of PRISm is significantly higher in high-altitude environments than in plain areas. High-altitude hypoxia may contribute to the development and progression of PRISm through multiple mechanisms, including induction of systemic inflammatory responses, oxidative stress injury, abnormal activation of hypoxia-inducible factor (HIF) signaling pathways, and an increased cardiopulmonary compensatory burden. However, direct evidence regarding the specific mechanisms involved still requires further investigation. Unique risk factors for PRISm in high-altitude regions include elevated white blood cell count, elevated red blood cell distribution width, and a history of tuberculosis. Current research on PRISm at high altitude faces challenges including a lack of diagnostic criteria, insufficient epidemiological data, and limited mechanistic exploration. Future efforts should focus on establishing altitude-specific reference values for lung function, conducting multicenter longitudinal cohort studies and multi-omics mechanistic research, developing appropriate screening and intervention tools, promoting interdisciplinary collaboration, and improving the comprehensive prevention and control system for PRISm in high-altitude regions.
PMID:
42557081
Bibliographic data and abstract were imported from PubMed on 06 Aug 2026.
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