Authors
Aoqian Qiu, Pan Ran, Yang Zhou, Beiyao Xiang, Luhan Dai, Chunhui Yang, Haowen Zhang, Jing Ma, Xu Cheng, Mengning Ding
Published in
Journal of the American Chemical Society. Aug 05, 2026. Epub Aug 05, 2026.
Abstract
Flow electrochemical synthesis is a promising platform for constructing value-added targets such as d-labeled compounds. However, its efficiency and broader application are limited by the unproductive or kinetically mismatched counter half-reactions and architectural constraints of conventional flow cell architectures. Here, we report a redox-decoupled strategy within a single-cell tandem flow reactor that separates a classical substitutive deborylation-deuteration into sequential electrochemical steps. This approach enables the universal, metal-free deuteration of diverse organoboron species, including boronic acids, borate esters, and borates, across alkyl, (heterocyclic) aryl, alkenyl, and other derivatives (>100 examples). Using D2O as a cost-effective d-source, the system achieves excellent yields, d-incorporation, tolerance to the labile functional groups, and significantly improved Faradaic efficiency. The platform demonstrates industrial-grade durability with continuous operation for over 1200 h and enables scalable, unprotected synthesis of deuterated drug d-mexiletine. Overall, this strategy significantly expands the design space of flow electrochemistry, paving an exciting path toward green, economic, and efficient electrosynthesis.
PMID:
42561327
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.
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