Early phase (day 1-day 3) profile and clinical significance of circulating miR-101 and miR-146a in adult sepsis.

Authors

Özlem Aldemir, Hatun Öztürk Çerik, Burcu Bayyurt, Murtaza Öz

Published in

Revista da Associacao Medica Brasileira (1992). Volume 72. Issue 6. Pages e20252209. Epub Jul 31, 2026.

Abstract

The aim of this study was to investigate serum miR-101 and miR-146a expression levels in adult sepsis, compare them with healthy controls, and assess their relationships with inflammatory markers and disease severity.
In total, 15 adults meeting Sepsis-3 criteria and 15 healthy controls were prospectively enrolled. Serum miR-101 and miR-146a levels were quantified by quantitative polymerase chain reaction within 24 h using the 2-∆Ct method and reassessed on day 3. Associations with clinical, laboratory, and disease severity parameters were analyzed.
On day 1, miR-101 expression was significantly higher in the sepsis group than in controls (1.17 vs. 0.14; p=0.011). miR-146a levels were lower in sepsis but did not differ significantly (p=0.152). Neither miRNA showed a significant change from day 1 to day 3 (miR-101: p=0.776; miR-146a: p=0.191). miR-101 demonstrated positive correlations with procalcitonin, white blood cell count, C-reactive protein, creatinine, and a negative correlation with albumin. Levels were markedly higher in patients with cardiovascular comorbidities (ρ=0.622; p=0.013). miR-101 correlated positively with Acute Physiology and Chronic Health Evaluation II (ρ=0.412; p=0.024), while no association was observed with Sequential Organ Failure Assessment. miR-146a showed no meaningful correlations with clinical or laboratory parameters.
miR-101 is significantly elevated in adult sepsis and reflects systemic inflammatory burden and disease severity; however, given its limited specificity, it should be considered a complementary biomarker rather than a standalone diagnostic or prognostic tool. Its stable expression between days 1 and 3 suggests a sustained early phase molecular response. miR-146a shows no significant change and has limited diagnostic relevance in adult sepsis. Larger multicenter studies are needed to validate these findings.

PMID:
42561192
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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