The association of total oxidant status, total antioxidant status, and ischemia-modified albumin levels with cervical human papillomavirus infection and cervical intraepithelial neoplasia.

Authors

Belgin Savran Ucok, Tugba Kinay, Ilknur Alkan Kusabbi, Murat Levent Dereli, Sadun Sucu, Turkan Dikici Aktas, Emel Ozalp, Ozgur Volkan Akbulut, Vakkas Korkmaz, Yaprak Engin Ustun

Published in

Revista da Associacao Medica Brasileira (1992). Volume 72. Issue 6. Pages e20252260. Epub Jul 31, 2026.

Abstract

The aim of this study was to evaluate the association between oxidative stress and cervical human papillomavirus infection and cervical intraepithelial neoplasia by measuring total oxidant status, total antioxidant status, and ischemia-modified albumin levels.
In total, 50 human papillomavirus+ women, 50 cervical intraepithelial neoplasia2/3+ women, and 50 healthy women as a control group were enrolled in the prospective case-control study. The total oxidant status, total antioxidant status, and ischemia-modified albumin levels were measured with colorimetric systems. The clinical characteristics, total oxidant status, total antioxidant status, and ischemia-modified albumin levels of three groups were compared.
The mean total antioxidant status level was higher in the control group (1.044±0.0959 mmol/L) than in the human papillomavirus+ group (0.931±0.1034 mmol/L) and the cervical intraepithelial neoplasia2/3+ group (0.927±0.0928 mmol/L) (p<0.001). The median total oxidant status level was lower in the control group than the cervical intraepithelial neoplasia2/3+ group (4.570 [4.390-4.783] μmol/L vs. 4.780 [4.443-5.035] μmol/L, p<0.05). The ischemia-modified albumin levels were similar in three groups (p=0.220).
The total antioxidant status level was lower, and the total oxidant status level was higher in women with cervical intraepithelial neoplasia2/3+ compared to the control group. These findings suggest that oxidative stress is effective in the progression of human papillomavirus infection to the preinvasive lesions of the cervix. The ischemia-modified albumin was not found to be a useful biomarker to indicate oxidative stress in women with human papillomavirus infection or cervical intraepithelial neoplasia2/3 lesions.

PMID:
42561193
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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