Authors
Ketilly Samilly de Souza Silva, Josefa Viviane de Moura Ferreira, Lara Louíse Pinto Câmara, Mylena Taise Azevedo Lima Bezerra, Sheila Andreoli Balen
Published in
CoDAS. Volume 38. Issue 5. Pages e20250244. Epub Aug 03, 2026.
Abstract
To analyze the neural response of the subcortical pathway through click and speech stimuli in infants and young children with congenital cytomegalovirus (CMVc).
Cross-sectional and prospective study. The sample consisted of infants and young children with a median age of 6.43 months (Q1-Q3: 2.62-11.25) in the CMV group (G1; n=10) and 6.23 months (Q1-Q3: 1.60-12.06) in the control group (G2; n=10). All participants underwent Transient Evoked Otoacoustic Emissions (TEOAE) and bilateral peak positive pressure tympanometry. The procedures included anamnesis, Auditory Brainstem Response with click stimulus (ABR-click), and Frequency Following Response (FFR). Click ABR was performed at intensities of 80 and 30 dB nHL in both ears. FFR was recorded in the right ear with a speech stimulus /da/ of 170 ms. FFR responses were analyzed in the temporal and spectral domains, regarding neural synchrony, spectral representation, and stability of the speech response. The Mann-Whitney test or Student's t-test was applied for intergroup analysis. The Wilcoxon test was applied for intragroup analysis.
In the analysis of click ABR latencies and amplitudes, as well as in FFR measurements related to subcortical neural coding of speech, no statistically significant differences were observed between groups or between ears in the intergroup analysis.
Preliminary results indicate a similar pattern of subcortical neural coding of speech and neural synchrony in infants and young children with and without CMVc.
PMID:
42561348
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.
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