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Obesity's immune memory: an epigenetic barrier to recovery.

Created on 07 Aug 2026

Authors

Helena L Fisk

Published in

Trends in endocrinology and metabolism: TEM. Aug 07, 2026. Epub Aug 07, 2026.

Abstract

Obesity leaves a lasting epigenetic imprint on adaptive immunity. A recent work by Niven et al. demonstrates that obesity-associated DNA methylation in CD4+ T lymphocytes persists after weight loss, sustaining inflammatory memory and delaying immune recovery. These findings suggest that treatment of obesity may require the restoration of immune homeostasis.

PMID:
42562710
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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