Studying the Natural History of the Knee Joint.

Authors

Kellen L Mulford, Marisa Ulrich, Sami Saniei, Cody C Wyles

Published in

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews. Volume 10. Issue 8. Aug 01, 2026. Epub Jul 31, 2026.

Abstract

By the time the orthopaedic surgeon sees a patient with symptomatic knee osteoarthritis, the disease has already progressed to an advanced stage. As a result, studying the full natural history of the knee is especially difficult. A few large longitudinal cohorts, the Osteoarthritis Initiative and Multicenter Osteoarthritis Study in particular, provide the bulk of the data for most extant studies. In this review, we report on the current state of knowledge regarding the study of the natural history of the knee, including the difficulties of natural history research, the tools used to assess knee osteoarthritis, the major longitudinal studies in knee osteoarthritis, and the ability of early interventions to modify natural history. In addition, we will preview what is possible using artificial intelligence and newer large longitudinal cohorts.

PMID:
42562370
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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