Toremifene-induced bilateral macular crystalline deposits with cystic cavitation: a case report.

Authors

Chunhuan Niu, Fei Wang, Jiao Li, Xiaotong Sun, Xiaofeng Xie, Yane Gao

Published in

Frontiers in medicine. Volume 13. Pages 1840738. Epub Jul 23, 2026.

Abstract

Tamoxifen-induced retinopathy is well recognized and frequently reported in clinical practice. By contrast, ocular adverse events associated with the structurally similar agent toremifene remain rarely described. We present a case of bilateral visual impairment in a patient receiving long-term oral toremifene citrate for secondary prevention after breast cancer surgery. Ophthalmic evaluation showed yellowish-white crystalline deposits within the macular retinal layers in both eyes. Optical coherence tomography (OCT) revealed cystic vacuolization in the bilateral foveal regions, with features closely resembling tamoxifen-induced retinopathy. A clinical diagnosis of toremifene-associated retinopathy was established. This case may provide reference for clinicians when judging the appropriate timing of toremifene withdrawal. Should drug cessation be considered, a joint assessment by ophthalmologists and oncologists should be performed to balance the risks of tumor progression and ocular damage before reaching a clinical decision. In addition, this case supplements available evidence regarding toremifene-related ocular toxicity and raises clinical awareness of this condition.

PMID:
42564483
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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