[Relationship between serum retinol-binding protein 4 and cystatin C and cardiac function and ventricular remodeling in patients with myocardial infarction].

Authors

Yuanyuan Niu, Jianping Fu, Hongbo Zhang

Published in

Zhonghua wei zhong bing ji jiu yi xue. Volume 38. Issue 7. Pages 655-660.

Abstract

To investigate the relationship between serum retinol-binding protein 4 (RBP4) and cystatin C (CysC) levels and cardiac function as well as ventricular remodeling in patients with myocardial infarction.
A case control study was conducted. A total of 185 patients with first diagnosed acute myocardial infarction (AMI) who were treated at Harrison International Peace Hospital between December 2022 and January 2025 were enrolled as the research subjects, and 150 healthy subjects who underwent physical examination at the same hospital during the same period were enrolled as the controls. Fasting peripheral venous blood samples were collected on the second day after admission for AMI patients and on the morning of physical examination for healthy controls. Serum levels of RBP4 and CysC were measured by an automatic biochemical analyzer. Cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD)] and ventricular remodeling indexes [left ventricular end-systolic volume (LVESV), left ventricular end-systolic posterior wall thickness (PWS), left ventricular remodeling index (LVRI), left ventricular mass (LVM)] were detected by color Doppler ultrasound. Pearson correlation analysis was used to analyze the correlations of serum RBP4 and CysC levels with cardiac impairment and ventricular remodeling in AMI patients. Receiver operator characteristic curve (ROC curve) was plotted to evaluate the predictive value of serum RBP4, CysC alone and their combination for cardiac impairment and ventricular remodeling in AMI patients.
No significant differences in gender and age were observed between the two groups (both P>0.05). Serum levels of RBP4 and CysC, as well as LVEDD, LVESV, PWS and LVM were significantly higher in the AMI group than those in the healthy control group [RBP4 (mg/L): 55.37±8.31 vs. 43.12±6.47, CysC (mg/L): 1.58±0.49 vs. 0.72±0.11, LVEDD (mm): 48.02±7.17 vs. 37.19±5.58, LVESV (mL): 67.42±10.11 vs. 48.61±7.29, PWS (mm): 13.52±1.03 vs. 9.36±1.10, LVM (g): 244.96±36.74 vs. 167.35±25.10, all P<0.05]. In contrast, LVEF and LVRI were significantly lower in the AMI group than those in the healthy control group [LVEF: 0.421±0.063 vs. 0.654±0.098, LVRI (g/mL): 0.85±0.13 vs. 1.24±0.19, both P<0.05]. Among 185 AMI patients, 64 were classified as Killip class I, 58 as class II, 44 as class III, and 19 as class IV. With the increase of Killip classification, serum RBP4 and CysC levels, LVEDD, LVESV, PWS and LVM were gradually elevated, while LVEF and LVRI were gradually decreased (all P<0.05). Pearson correlation analysis showed that serum RBP4 and CysC were negatively correlated with LVEF (r values were -0.453 and -0.424, respectively) and LVRI (r values were -0.479 and -0.443, respectively, all P<0.05), and positively correlated with LVEDD (r values werre 0.202 and 0.297, respectively), LVESV (r values were 0.248 and 0.267, respectively), PWS (r values were 0.285 and 0.272, respectively) and LVM (r values were 0.291 and 0.228, respectively, all P<0.05). ROC curve analysis indicated that serum RBP4 and CysC alone had moderate predictive value for cardiac impairment and ventricular remodeling in AMI patients, and the combined detection achieved higher predictive efficacy. The area under the ROC curve (AUC) with 95% confidence interval (95%CI) was 0.924 (0.863-0.984) and 0.913 (0.849-0.976), with sensitivity of 89.91% and 90.14%, and specificity of 88.92% and 88.68%, respectively.
Serum RBP4 and CysC levels are significantly elevated in AMI patients and are closely related to the severity of cardiac impairment (Killip classification, LVEF, LVEDD) and ventricular remodeling (LVESV, PWS, LVM, LVRI). Combined detection of serum RBP4 and CysC shows high predictive value for cardiac impairment and ventricular remodeling in AMI patients.

PMID:
42563680
Bibliographic data and abstract were imported from PubMed on 07 Aug 2026.

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