Authors
Giorgio Nicoletti, Antonio Celani
Published in
PLoS computational biology. Volume 22. Issue 8. Pages e1014585. Aug 07, 2026. Epub Aug 07, 2026.
Abstract
Understanding how living organisms process sensory information from their surroundings and translate it into decisions is a fundamental problem across biological scales - from biochemical signalling in single-cells to neural computations in animal brains. In this work, we address this challenge by introducing a method to reconstruct general decision processes directly from behavioral observations alone. Our approach is applicable to any biological agent and does not require prior knowledge of its internal mechanisms or its environment. Our agent model is defined by a recurrent dynamics over a discrete set of internal states which encode and process sensory information, and dictate which actions to execute. We validate our method on synthetic agents and demonstrate that we can exactly recover the agent's behavior for non-trivial tasks. Then, we infer agent models from experimental data of rats performing evidence accumulation and of mice making decisions under uncertainty and in changing environments. In both cases, very few internal states suffice to reproduce the observed behavior with high accuracy. Crucially, the immediate interpretability of the inferred dynamics allows to understand the computational process underlying decision-making.
PMID:
42566485
Bibliographic data and abstract were imported from PubMed on 08 Aug 2026.
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