Authors
Xinjuan Liu, Qing Dong, Yuhui Sun, Juefei Wu, Xueli Zhao, Chu Chu, Tianyi Li, Daiyong Chao, Gang Ding
Published in
Advanced healthcare materials. Pages e71523. Aug 07, 2026. Epub Aug 07, 2026.
Abstract
Diabetic chronic wounds, as a prevalent and serious complication of diabetes, pose serious threats to patient health and survival, underscoring the urgent need for effective therapeutic strategies. Stem cell therapy has emerged as a promising approach, but its efficacy is often compromised by the hostile wound microenvironment, characterized by excessive reactive oxygen species and persistent inflammation. To address this challenge, we developed a nanozyme-based engineering strategy to enhance the therapeutic potential of periodontal ligament stem cells (PDLSCs) based on a bimetallic CuNi-MOF nanozyme exhibiting dual superoxide dismutase- and catalase-like activities. In vitro experiments demonstrated that, the CuNi-MOF nanozyme effectively alleviated oxidative stress and reduced cellular senescence in PDLSCs. Mechanistic investigation revealed the involvement of the JNK/ERK signaling axis in this protective effect. In a diabetic wound model, nanozyme-engineered PDLSCs (E-PDLSCs), exhibited superior healing compared with untreated PDLSCs. Specifically, E-PDLSCs significantly accelerated re-epithelialization, enhanced collagen deposition, and promoted angiogenesis, while also modulating inflammatory cytokine levels and macrophage polarization. Overall, this study presents a cell engineering strategy that integrates antioxidant nanozymes with stem cells for chronic wound treatment, extending the potential applications of nanozyme in regenerative medicine.
PMID:
42568052
Bibliographic data and abstract were imported from PubMed on 08 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 1
- Comments 0