Rapid assembly of structurally diverse 3,4-dihydroquinazolines with anticancer activity via SDS-promoted aqueous synthesis.

Authors

Fu-Qiang Yu, Pei-Lu Song, Yan-Rui Fan, Jun-Wei Wang, Xu-Jie Wang, Jin-Fei Yang

Published in

Molecular diversity. Aug 07, 2026. Epub Aug 07, 2026.

Abstract

A convenient SDS-promoted strategy enables the synthesis of a 42-member library of structurally diverse 3,4-dihydroquinazolines in an aqueous medium. The protocol features mild reaction conditions, operational simplicity, and facile scalability. Synthetic transformations highlight the versatility of the scaffold, while preliminary biological evaluation identifies compound 3v as a promising inhibitor against U87 glioblastoma cells.

PMID:
42568006
Bibliographic data and abstract were imported from PubMed on 08 Aug 2026.

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