Authors
Dong Xu, Huanhuan Zhang, Zhiyan Piao, Yong He, Haiyan Li, Nan Zhang
Published in
International psychogeriatrics. Pages 100255. Aug 07, 2026. Epub Aug 07, 2026.
Abstract
This study explored whether distinct Alzheimer's disease (AD) structural atrophy subtypes exhibit divergent functional profiles.
A cross-sectional multimodal neuroimaging and electrophysiological study.
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
A total of 116 patients with AD and 74 cognitively unimpaired controls underwent structural MRI. Patients with AD were stratified into three MRI-derived atrophy-pattern groups corresponding to hippocampal-sparing (HpSp-MRI), typical (tAD-MRI), and limbic-predominant (LP-MRI) subtypes.
Resting-state functional MRI was used to assess intra- and internetwork functional connectivity, and EEG was used to evaluate spectral power and microstate dynamics.
The HpSp-MRI subtype showed lower intranetwork connectivity than both the LP-MRI and tAD-MRI subtypes in the visual, somatomotor, and dorsal attention networks. The LP-MRI and tAD-MRI subtypes differed in ventral attention network connectivity. Moreover, the LP-MRI subtype exhibited stronger internetwork connectivity in specific network pairs compared with the other subtypes. EEG analysis suggested a possible difference in the microstate 3-to-1 transition between the LP-MRI and tAD-MRI groups.
MRI-derived atrophy-pattern subtypes showed different resting-state functional connectivity profiles, providing a potential basis for personalized brain network-targeted interventions in AD.
PMID:
42567790
Bibliographic data and abstract were imported from PubMed on 08 Aug 2026.
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