Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort.

Authors

Tajidine Tsiavia, Joseph Henny, Emilie Fréalle, Marcel Goldberg, Céline Ribet, Marie Zins, Nicolas Roche, Bénédicte Leynaert, Laurent Orsi, Rachel Nadif

Published in

Thorax. Aug 07, 2026. Epub Aug 07, 2026.

Abstract

Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma.Among 1870 adults with current asthma from a population-based cohort, 29.6% reported visible mould in the dwelling. Paucigranulocytic (reference category), neutrophilic, eosinophilic and mixed phenotypes accounted for 58.8%, 3.8%, 34.5% and 2.9%, respectively. Visible mould was consistently associated with eosinophilic phenotype (OR 1.30 (95% CI 1.04 to 1.63)) whatever the analyses, with no heterogeneity by sex.Our findings suggest that mould contamination may contribute to type 2 inflammation, offering mechanistic insight into the effect of mould on asthma in adults.

PMID:
42567702
Bibliographic data and abstract were imported from PubMed on 08 Aug 2026.

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