Clinical outcomes in patients hospitalized for COVID-19 in the periods of non-Omicron and Omicron variant dominance.

Authors

Yi-Jhen Hsieh, Bing-Chen Wu, Shih-Wei Huang, Chen-Chuan Hsu, Hsin-I Cheng, Ko-Wei Chang, Allen Chung-Cheng Huang, Chang-Wei Lin, Ting-Yu Lin, Horng-Chyuan Lin, Cheng-Hsun Chiu, Shu-Min Lin

Published in

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. Aug 08, 2026. Epub Aug 08, 2026.

Abstract

Omicron is known for its higher transmissibility and milder respiratory symptoms than those of other SARS-CoV-2 variants. How comorbidities contribute to mortality outcomes in Omicron-related COVID-19 remains unclear. This study compared clinical features and outcomes between Omicron and non-Omicron variants and identified risk factors for in-hospital mortality.
This retrospective cohort study was conducted from April 2020 to September 2022. Patients with COVID-19 infection were divided into Omicron and non-Omicron groups. Demographic data, laboratory results, and treatment information were collected and analyzed. Clinical outcomes for different variants were analyzed.
The Omicron group had a greater burden of comorbidities but exhibited lower COVID-19 disease severity and fewer complications than did the non-Omicron group. Overall mortality was relatively high in the Omicron group, primarily due to non-COVID-related causes. In multivariate analysis, a Charlson comorbidity index score of ≥3 (odds ratio [OR] = 4.60, 95% confidence interval [CI] = 1.94-10.91, p < 0.001), severe or critical COVID-19 (OR = 1.60, 95% CI = 1.24-2.07, p < 0.001), a high white blood cell count (OR = 1.00, 95% CI = 1.00-1.00, p = 0.021), and a high C-reactive protein level (OR = 1.01, 95% CI = 1.00-1.01, p = 0.003) emerged as positive predictors of COVID-19-related mortality.
Severe or critical COVID-19 and a Charlson comorbidity index score of ≥3 were independently associated with high in-hospital mortality. Intensive monitoring and early intervention should be prioritized for high-risk groups to improve clinical outcomes.

PMID:
42570879
Bibliographic data and abstract were imported from PubMed on 09 Aug 2026.

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