Comparison of 2015 and 2025 ATA Risk Stratification Systems for Predicting Recurrence in Papillary Thyroid Carcinoma.

Authors

Ji Hyun Yoo, Sungjoo Lee, Bo Ram Kim, Hyunju Park, Da Eun Leem, Hyun Jin Ryu, Joon-Hyop Lee, Hye In Kim, Jae Hoon Chung, Sun Wook Kim, Tae Hyuk Kim

Published in

Annals of surgical oncology. Aug 08, 2026. Epub Aug 08, 2026.

Abstract

The 2025 American thyroid association (ATA) guidelines introduced a revised risk stratification system for thyroid cancer incorporating histology-specific models and a four-tier classification framework. However, its clinical performance in patients with papillary thyroid carcinoma (PTC) remains insufficiently validated. This study compared the 2015 and 2025 ATA risk stratification systems for predicting PTC recurrence and evaluated reclassification patterns.
This retrospective cohort study included 284 patients who underwent surgery for PTC at Samsung Medical Center, Seoul, Korea, between 2019 and 2021. Risk classification was performed according to the 2015 ATA three-tier system (low, intermediate, and high risk) and the 2025 ATA four-tier system (low, low-intermediate, intermediate-high, and high risk). Predictive performance for recurrence was assessed using disease-free survival (DFS) and the integrated area under the receiver operating characteristic curve (iAUC).
During follow-up, structural recurrence occurred in 23 patients (8.1%). Under the 2015 system, recurrence occurred in 0/119 low-risk, 8/106 intermediate-risk, and 15/59 high-risk patients. Under the 2025 system, recurrence occurred in 0/86 low-risk, 1/56 low-intermediate-risk, 2/53 intermediate-high-risk, and 20/89 high-risk patients, with recurrence events predominantly concentrated in the high-risk group. The 2025 ATA system resulted in substantial reclassification, particularly among patients initially classified as intermediate risk. The iAUC for predicting DFS was 0.873 for the 2015 system and 0.852 for the 2025 system.
The 2025 ATA risk stratification system demonstrated predictive performance comparable to the 2015 system while concentrating recurrence events predominantly within the high-risk group, suggesting improved risk discrimination in patients with PTC.

PMID:
42570987
Bibliographic data and abstract were imported from PubMed on 09 Aug 2026.

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