Myeloid-derived suppressor cells mitigate inflammation in periodontal disease.

Authors

Raza Ali Naqvi, Araceli Valverde, Salvador Nares, Thomas E Van Dyke, Afsar R Naqvi

Published in

iScience. Volume 29. Issue 8. Pages 116981. Aug 21, 2026. Epub Jul 29, 2026.

Abstract

Myeloid-derived suppressor cells (MDSCs) are immature, immunosuppressive myeloid cells whose role in periodontal disease (PD) is not well defined. Here, we show that gingiva from PD patients exhibit increased infiltration of MDSCs, including granulocytic (G-MDSC) and monocytic (M-MDSC) subsets, alongside elevated CD4⁺ T cells and CD19⁺ B cells. Functionally, these MDSC subsets suppress autologous CD4⁺ T cell proliferation in co-culture, confirming their immunoregulatory capacity. In a murine ligature-induced periodontitis (LIP) model, both gingival MDSC subsets increased over time and correlated with CD4⁺ T cell and CD19⁺ B cell infiltration. Adoptive transfer of G-MDSCs and M-MDSCs into LIP mice reduced gingival CD4⁺ T cell infiltration and pro-inflammatory cytokines, while increasing arg1, Il-10, and CD4⁺CD25+FoxP3+ Tregs. In contrast, anti-Gr-1 depletion exacerbated periodontal inflammation, reduced Treg counts, and increased alveolar bone loss. Collectively, these findings identify anti-inflammatory and osteoprotective roles for MDSCs in PD and support their therapeutic potential for periodontal inflammation.

PMID:
42571330
Bibliographic data and abstract were imported from PubMed on 09 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.