Secondary Adrenal Insufficiency Presenting With Severe Hyponatremia in an Elderly Patient With Primary Aldosteronism Suggesting Underlying Autonomous Cortisol Secretion.

Authors

Minami Toda, Shunsuke Takahashi, Hitomi Saito, Honami Mori, Yutaka Kuroda, Akito Maeshima

Published in

Clinical case reports. Volume 14. Issue 8. Pages e73303. Epub Aug 07, 2026.

Abstract

Possible unrecognized cortisol autonomy in primary aldosteronism may suppress the hypothalamic-pituitary-adrenal axis. Under physiological stress, this may contribute to secondary adrenal insufficiency and severe hyponatremia. Clinicians should consider adrenal insufficiency in patients with primary aldosteronism presenting with unexplained clinical deterioration.

PMID:
42571142
Bibliographic data and abstract were imported from PubMed on 09 Aug 2026.

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