ETAS reduces wake time after sleep onset in healthy adults who are dissatisfied with their sleep: A randomized, placebo-controlled, double-blind crossover study.

Authors

Manami Misu, Kazunori Goto, Jun Takanari

Published in

Sleep medicine: X. Volume 12. Pages 100196. Dec 15, 2026. Epub Jul 24, 2026.

Abstract

Poor sleep quality is strongly associated with health indicators. Specifically, it increases the risk of developing diseases, including coronary artery disease and type 2 diabetes. Our preliminary study suggested that ETAS, a standardized extract of Asparagus officinalis stem, may enhance the proportion of N3, a stage of deep sleep. In this study, we conducted an expanded, randomized, placebo-controlled, double-blind crossover study to investigate the effect of ETAS on N3 appearance. The study included 38 healthy adult participants with sleep dissatisfaction. Intervention periods involved administration of either placebo or ETAS (300 mg/day as ETAS50) for 14 days, with a 14-day washout period between periods. The primary endpoints were the proportion of N3 sleep after the intervention, as determined by electroencephalogram (EEG) analysis. Secondary endpoints included sleep parameters indices other than the proportion of N3 as determined by EEG analysis after the intervention, as well as OSA-MA and AIS-J scores. 14-day ETAS intake did not result in a statistically significant difference in the proportion of N3. In contrast, wake time after sleep onset (WASO) and the total time of N1 significantly decreased. In addition, ETAS intake improved the following scores for AIS: total score, "awakenings during the night" and "functioning capacity during the day". Furthermore, post-hoc analysis revealed that ETAS intake significantly reduced WASO in individuals who originally had high WASO and significantly improved sleep efficiency in individuals with low sleep efficiency. These results suggest that ETAS may regulate sleep quality in accordance with the individual's sleep stage balance.

PMID:
42571331
Bibliographic data and abstract were imported from PubMed on 09 Aug 2026.

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