Myromopholine A, a new unusual diketomorpholine from Myrothecium gramineum.

Authors

Run-Qiao Kuang, Hui-Jun Huang, Shu-Tai Jiang, Guo-Dong Chen, Huan Zhao, Dan Hu, Xing-Zhong Liu, Chuan-Xi Wang, Hao Gao, Xin-Sheng Yao

Published in

Journal of Asian natural products research. Pages 1-8. Aug 09, 2026. Epub Aug 09, 2026.

Abstract

A new diketomorpholine, myromopholine A (1), was isolated from the wetland fungus Myrothecium gramineum (ZLW0801-19). Through extensive spectroscopic analyses, including IR, MS, NMR, and X-ray single crystal diffraction, the planar structure and absolute configuration of the compound were determined, revealing the presence of a rare D-phenyllactic acid moiety. The investigation represents the first reported isolation of a diketomorpholine compound from the genus Myrothecium. Furthermore, it is the first identification of a diketomorpholine bearing a D-phenyllactic acid unit from a natural source, challenging the conventional understanding that such natural products exist exclusively as L-form derivatives.

PMID:
42571711
Bibliographic data and abstract were imported from PubMed on 10 Aug 2026.

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