Authors
Tianbao Wang, Yaqin Yang, Ya Zhuo, Aihui Li, Changyun Si, Yanping Wang, Xueyan Hou
Published in
International journal of pharmaceutics. Pages 127297. Aug 09, 2026. Epub Aug 09, 2026.
Abstract
Bacterial infection severely impairs wound healing, and current therapeutic strategies are limited due to their poor antibacterial efficacy and potential bio-toxicity. Herein, a novel multifunctional hydrogel (CGBAgel) was fabricated with glutathione-modified carboxymethyl cellulose (CMC-GSH) and bovine serum albumin (BSA) as matrixes. Levofloxacin (LEV) was selected as an anti-bacterial agent and encapsulated in CGBAgel to fabricated LEV@CGBAgel. Studies found that LEV@CGBAgel exhibited favorable physicochemical properties, robust broad-spectrum antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) strains, excellent biocompatibility, negligible cytotoxicity, and potent hemostatic and adhesive performance. In a mouse model of S. aureus-infected full-thickness skin wounds, LEV@CGBAgel achieved almost complete bacterial clearance, significantly accelerated wound closure with a closure rate of 99.9 ± 0.1% at 14 d, and promoted skin tissue regeneration. At the mechanistic level, LEV@CGBAgel mitigated local inflammation by inhibiting pro-inflammatory cytokines (TNF-α, IL-6), accelerated angiogenesis via upregulating VEGF and CD31, and promoted extracellular matrix remodeling by boosting collagen deposition. The in vivo safety evaluations confirmed that LEV@CGBAgel did not induce systemic, hematological, hepatic, or renal toxicity. Collectively, LEV@CGBAgel integrates multiple wound-healing functions with superior biosafety, holding great clinical translation potential for bacteria-infected wound management.
PMID:
42571803
Bibliographic data and abstract were imported from PubMed on 10 Aug 2026.
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