Authors
Yu Chen, Qingtao Liu, Kun Liu, Chuanchao Wu, Mengkai Hu, Tianwen Wang, Zhenglian Xue, Yan Liu
Published in
Molecular biology reports. Volume 53. Issue 1. Aug 10, 2026. Epub Aug 10, 2026.
Abstract
Epigenetic regulation plays a central role in metabolic gene expression in eukaryotes. Focusing on Saccharomyces cerevisiae as a model, this review systematically examines how histone modifications, including acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation, and ATP‑dependent chromatin remodeling regulate metabolic genes. It also summarizes the crosstalk between metabolic signals and epigenetic states. On this basis, practical progress, advantages, and limitations of applying these mechanisms in metabolic engineering are then discussed, including industrial strain optimization and the development of epigenetic molecular tools, as well as their technical limitations and scale-up challenges. In addition, yeast models for human diseases are introduced, covering tumor-associated histone dysregulation and antifungal drug resistance. Future research should focus on elucidating the dynamic and combinatorial mechanisms of epigenetic regulation, the direct regulation of chromatin remodeling complexes by metabolic signals, and the development of more precise and stable regulatory strategies. These findings provide insights into metabolic regulation in higher eukaryotes and lay a foundation for industrial biotechnology, synthetic biology, and disease research.
PMID:
42573893
Bibliographic data and abstract were imported from PubMed on 10 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 6
- Comments 0