A Prospective Case Series on the Effect of Cross-Linked Hyaluronic Acid Combined With a Collagen Sponge in the Treatment of Alveolar Osteitis.

Authors

Danijel Domic, Peter Bauer, Nicola Ottenbacher, Kristina Bertl, Christian Ulm, Andreas Stavropoulos

Published in

Clinical and experimental dental research. Volume 12. Issue 4. Pages e70388.

Abstract

This case series reports on alveolar osteitis (AO) treatment outcomes after standard AO therapy combined with cross-linked hyaluronic acid (xHyA) and a collagen sponge.
Nine patients fulfilling the AO criteria after permanent tooth extraction were included. After standard AO treatment, that is, irrigation and curettage, a xHyA gel combined with an absorbable collagen sponge was applied into the socket and stabilized with a suture. Pain perception (visual analogue scale [VAS], pain killer consumption), soft tissue healing index (STHI), alveolar bone exposure, necessity of re-treatment, occurrence of complications, and patients' opinion were assessed up to 14 days post-treatment.
Eight patients completed the 14-day follow-up, while one patient dropped out after 1 day due to persisting pain. Initial mean pain perception (VAS) was 7.5 (1.4), which decreased after a single treatment to 4.4 (2.2) within 6 h and by 50% (3.8 [2.4]) within 24 h. In 5 out of 8 patients, complete pain resolution was achieved after 14 days, while 3 patients still experienced moderate pain. Pain reduction was accompanied by an improvement of STHI, reaching 4.0 (0.8) within 14 days; complete coverage of exposed alveolar bone walls was already observed within 3 days in all 8 patients. Only one patient required re-treatment; 5 out of 8 patients expressed willingness to pay on top between 50 and 300€ for the material costs (xHyA+collagen sponge).
A single application of xHyA combined with a collagen sponge offered effective and fast pain relief combined with a favorable healing process in patients suffering from AO. Furthermore, the need for re-treatment was infrequent, and favorable patient feedback was observed. However, randomized controlled trials with a sufficient sample size and a control group are essential to validate these findings.

PMID:
42574577
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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