Dynamic expression of CD9 protein in T-cell acute lymphoblastic leukemia.

Authors

Julie Quessada, Mathis Nozais, Charlotte Savey, Julien Rey, Delphine Potier, Marie Loosveld, Dominique Payet-Bornet

Published in

Cancer gene therapy. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy affecting both children and adults. Given its persistently poor prognosis, there is a critical need to identify additional factors involved in T-ALL oncogenesis and progression. CD9, a membrane protein of the tetraspanin family implicated in diverse cellular processes, has been associated with prognosis in several cancers, yet its role in T-ALL remains poorly understood. In this study, using a mouse model first, we found that CD9 overexpression is associated with leukemic T cells that have migrated outside the thymus into peripheral tissues. Then, analysis of a human T-ALL cohort shows that CD9 expression is heterogeneous, tends to increase at relapse and is enriched in the TAL1⁺ molecular subtype. We further demonstrate that CD9⁺ cells display enhanced migratory capacity compared with CD9⁻ counterparts, and that CD9 levels affect extracellular vesicle biogenesis. Altogether, our findings support a role for CD9 in T-ALL leukemogenesis and highlight its potential involvement in relapse.

PMID:
42576053
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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