Challenging bone biopsies: what radiologists needs to know.

Authors

Leonor Garbin Savarese, Nicolas Papalexis, Mateus de Andrade Hernandes, Paolo Spinnato, Giancarlo Facchini, Marco Miceli, Nelson Fabricio Gava, Edgard Eduard Engel, Marcello Henrique Nogueira-Barbosa

Published in

Skeletal radiology. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

Bone biopsies play a pivotal role in the diagnostic workup of a wide range of bone pathologies. In many cases, image-guided percutaneous biopsy is favored over surgical approaches because it is minimally invasive, highly accurate, cost-efficient, and associated with lower morbidity. Among the available imaging modalities, CT guidance offers superior spatial resolution and enables precise needle placement, but certain skeletal locations remain technically demanding even under CT guidance. This review focuses on challenging CT-guided bone biopsy scenarios, including lesions adjacent to critical neurovascular or spinal structures, densely sclerotic lesions, and lesions occult on CT, and illustrates practical decision-making through representative clinical cases.

PMID:
42576100
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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