Radiation Therapy-Induced Valvular Heart Disease: A Comprehensive Review with a Multi-Modality Imaging and Multidisciplinary Approach.

Authors

Deya A Alkhatib, Emmanuel Akintoye, Mohamad Khattab, Samuel W Reinhardt, Lauren A Baldassarre

Published in

Cardiology clinics. Volume 43. Issue 1S. Pages e1-e13. Epub Jun 12, 2026.

Abstract

The increasing number of cancer survivors has highlighted the long-term cardiovascular implications of cancer treatment. Despite improvements in thoracic radiation therapy (RT) and cardiac sparing techniques, associated cardiovascular disease, most notably valvular heart disease (VHD), poses a significant challenge for cancer survivors. This systematic review examines the pathophysiology, prevalence, diagnosis, and treatment of VHD in cancer patients, with a focus on RT-related VHD, emphasizing the need for active surveillance and multidisciplinary care. The incidence of VHD increases over time post-radiation exposure. Valve regurgitation is more common than stenosis, with the aortic valve being most frequently affected.

PMID:
42575669
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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