Amyloidogenic amylin signaling links diabetes to dementia pathogenesis.

Authors

Florin Despa, Tammaryn Lashley

Published in

Trends in pharmacological sciences. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

Recent studies identify amyloidogenic human amylin, secreted by the pancreas, as a potential link between type-2 diabetes and Alzheimer's disease. Evidence suggests that pathogenic amylin signaling impairs cerebral bioenergetics, promoting tau hyperphosphorylation and neurodegeneration. Selective targeting of circulating amyloidogenic amylin and its pathogenic signaling may enable biomarker development and disease-modifying therapies.

PMID:
42575819
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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