Authors
Justin B Ziemba, Amanda Jones, Hanna Stambakio, Gregory E Tasian, Jing Huang
Published in
Urology. Aug 10, 2026. Epub Aug 10, 2026.
Abstract
To examine item level changes in PROMIS pain interference and ability to participate in social roles and activities following ureteroscopy (URS).
A prospective cohort study was conducted at a single academic center from 2020-2022. Adults undergoing URS for nephrolithiasis completed PROMIS pain interference (computer-adaptive test, 15 subdomains) and ability to participate in social roles and activities (short-form 8a, 8 subdomains) at baseline and at postoperative days (POD) 1, 7, 14, and 30. The primary outcome was a minimal clinically important difference (MCID, ≥5 points) in T-score from baseline to POD 1. Pairwise comparisons were assessed for change from baseline to each POD using linear mixed-effects models.
A total of 178 participants were enrolled. For pain interference, only 2 of 15 items - work around the home and day-to-day activities - demonstrated a statistically and clinically significant worsening at POD 1 (change +5.9 and +5.7, respectively; both p<0.01), persisting through POD 7 before recovering by POD 30. In contrast, 6 of 8 social participation items worsened significantly at POD 1 (change -5.2 to -6.8 points; all p<0.01), with full recovery by POD 30.
URS produces a specific, task-limited impact on pain interference but a comprehensive reduction in social participation both in and outside the home. These item-level findings offer actionable targets for patient counseling and anticipatory guidance prior to surgery.
PMID:
42575365
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.
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