Associations between aromatic amines and oxidative stress biomarkers among pregnant women in the San Francisco Bay Area of California.

Authors

Madeline Chandler, Tracey J Woodruff, Rachel Morello-Frosch, Amy M Padula, Kurunthachalam Kannan, Ginger L Milne, Stephanie M Eick

Published in

Environmental research. Pages 125433. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

Aromatic amines (AAs) have rarely been studied in the context of pregnancy despite their ubiquity and known toxicity. To our knowledge, no study has investigated the relationship between AAs and F₂-isoprostanes, which are linked to adverse maternal and child health outcomes.
Our analytic sample included 176 participants from the Chemicals in Our Bodies prospective birth cohort. Thirty-six AAs and four F₂-isoprostanes (biomarkers of oxidative stress) were measured in mid-pregnancy urine. We focused on six AAs that were detected in at least 50% of participants and calculated their molar sum (ΣAA). An additional six AAs that were detected in 20-49% of participants were analyzed as binary variables. Generalized additive mixed models were used to assess non-linearity, and linear regression models were used to examine associations between individual AAs and individual oxidative stress biomarkers, adjusting for confounders.
Most AAs were associated with significant increases in oxidative stress biomarkers. Increasing concentrations of ΣAA were significantly associated with 8-iso-PGF_2α (β=0.25, 95% confidence interval [CI]=0.1, 0.41) and PGF_2α (β=0.21, CI=0.04, 0.39). Additionally, the individual AAs o/m-toluidine and 4-chloroaniline were associated with significant increases in 8-iso-PGF_2α and PGF_2α.
Our study is the first to investigate the relationship between AAs and F₂-isoprostanes during pregnancy. This study found that several AAs are associated with higher levels of oxidative stress, highlighting one potential mechanism linking AAs to adverse maternal-child health outcomes.

PMID:
42575185
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.