An automated geometric modeling framework in GATE for the design and optimization of high-sensitivity converging-beam SPECT collimators.

Authors

Fenghua Weng, Gaoyu Chen, Yunlong Zan, Greta S P Mok, Youngho Seo, Qiu Huang

Published in

Physics in medicine and biology. Aug 10, 2026. Epub Aug 10, 2026.

Abstract

Objective:The trade-off between detection sensitivity and spatial resolution is a fundamental challenge in designing organ-dedicated SPECT collimators. While converging-hole geometries offer a solution, their optimization is often hindered by the lack of flexible computational tools capable of modeling large-scale, non-parallel hole arrays. This study aims to develop an automated geometric modeling framework to facilitate the design and evaluation of complex converging- and diverging-hole collimators within standard Monte Carlo environments. Approach:We developed a specialized modeling framework by implementing custom C++ classes and a vector-based alignment algorithm within GATE. This platform enables automated, orientation-consistent construction of large-scale converging arrays not natively supported by standard implementations. A high-sensitivity pure cone-beam collimator (CBC) was designed using this framework. The evaluation used hot-rod, disc, and Jaszczak phantoms for physical characterization, while XCAT and dedicated brain models were employed for clinical tasks, including cardiac, brain perfusion, and DaTscan SPECT simulations. Main results:The CBC achieved a nearly fourfold sensitivity increase compared to a conventional low-energy high-resolution (LEHR) parallel-hole collimator at a 20 cm radius of rotation, while maintaining comparable spatial resolution. Despite a 52.3% FOV reduction, the CBC yielded a 2.2-fold noise reduction (CV: 11.7% vs. 25.9%) and mitigated PVE via geometric magnification. XCAT and brain phantom simulations confirmed enhanced anatomical definition and contrast recovery in cardiac, perfusion, and DaTscan tasks. Significance:This work provides an efficient computational tool for rapid design space exploration of advanced collimator geometries. The results demonstrate that the proposed CBC design offers a significant sensitivity advantage, making it highly suitable for high-performance, small-volume clinical applications such as brain and cardiac molecular imaging. \end{abstract}.

PMID:
42575160
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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