Authors
Hiroki Usuku, Eiichiro Yamamoto, Fumi Oike, Naoto Kuyama, Masanobu Ishii, Shinsuke Hanatani, Tadashi Hoshiyama, Hisanori Kanazawa, Yuichiro Arima, Yasuhiro Izumiya, Yu Kawada, Shuichi Kitada, Nobuyuki Ohte, Yoshihiro Seo, Kenichi Tsujita
Published in
Circulation reports. Volume 8. Issue 8. Pages 1299-1307. Aug 10, 2026. Epub Jun 23, 2026.
Abstract
This study aimed to evaluate the prognostic impact of left ventricular (LV) regional longitudinal strain (LS) in patients with immunoglobulin light-chain (AL) cardiac amyloidosis.
The study population was part of the Japan Cardiac Amyloidosis Survey of typical Echocardiographic findings (J-CASE) study - a multicenter, retrospective study with 18 participating institutions in Japan. From a total of 324 patients with histologically proven cardiac amyloidosis enrolled between 2000 and 2020, we enrolled 81 patients with AL cardiac amyloidosis in the present study. During a median follow up of 278 days (interquartile range 63-1,133 days), 43 all-cause deaths occurred. LV-apical LS was significantly and independently associated with all-cause death after adjusting for conventional echocardiographic findings (hazard ratio 0.86; 95% confidence interval; P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve for LV-apical LS for all-cause death was 68% and the best cut-off value for LV-apical LS was 15.9% (sensitivity 71%; specificity 54%). Kaplan-Meier analysis demonstrated a significantly higher risk of all-cause death in patients with low LV-apical LS (<15.9%, n=46) than in those with high LV-apical LS (≥15.9%, n=35; log-rank test P<0.05).
Low LV-apical LS is a significant and independent prognostic factor in patients with AL cardiac amyloidosis.
PMID:
42577442
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 7
- Comments 0