[The role of the nasal microbiome in regulating upper airway immune homeostasis].

Authors

Xiaoxue Lin, Ziqing Chen, Biaoqing Lu, Guanjiang Huang

Published in

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery. Volume 40. Issue 8. Pages 777-782.

Abstract

The nasal microbiome serves as a pivotal regulator of immune homeostasis in the upper airway. Under physiological conditions, it maintains immune equilibrium through mechanisms such as reinforcing the epithelial barrier and modulating innate and adaptive immune responses. Microbial dysbiosis, however, is recognized as a key trigger in the pathogenesis of chronic rhinosinusitis （CRS） and allergic rhinitis （AR）. This review summarizes how the nasal microbiome regulates immune homeostasis by influencing epithelial barrier function and immune responses in both health and disease states, with a focus on CRS and AR. It focuses on the characteristics of microbial dysbiosis and immunopathological mechanisms in CRS and AR, and provides perspectives on microbiome-based diagnostic biomarkers and microecological interventional therapeutic strategies.

PMID:
42576645
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.

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