Authors
Krishna Patel, Monica Chavan, Jigna Shah, Shruti Chatterjee
Published in
Archives of microbiology. Volume 208. Issue 11. Aug 11, 2026. Epub Aug 11, 2026.
Abstract
A commensal organism has transformed into the leading multidrug resistant (MDR) hospital acquired pathogen, with serious implication on global public health. The ability of Enterococcus faecium to rapidly adapt through its great genomic plasticity, horizontal gene transfer and under selective pressures created by heavy antibiotic application both clinically and non-clinically is responsible for the phenomenon. Comparative genome studies have reported the presence of different community acquired and hospital acquired clades; hospital acquired clones being particularly the clonal complex 17 have enriched antibiotic resistant genes, mobile genetic elements, virulence factors. Therapeutic choices are now restricted, while mortality and morbidity increase due to lack of adequate drug targets, resistant to penicillin, vancomycin, linezolid and daptomycin. This review critically discuss the finding about the evolutionary history, diversity of genome, resistant mechanisms and global resistant trends of E. faecium's evolution into the hospital associated strain. The clinical and public health importance of MDR E. faecium is reviewed within the context of one health including the integrated roles of human, animal, and environment as reservoirs. Lastly, the review highlights the importance of integrated genomic surveillance, novel therapy approaches and an enhanced antimicrobial stewardship program according to World Health Organization priorities in the global fight against MDR E. faecium.
PMID:
42579153
Bibliographic data and abstract were imported from PubMed on 11 Aug 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 3
- Comments 0