Accelerated Brain Aging in Type 1 Diabetes Across Painful and Painless Peripheral Neuropathy: MRI-Based Brain Age Estimates From Deep Learning.

Authors

Søren N F Hostrup, Suganthiya S Croosu, Johan Røikjer, Carsten D Mørch, Christina Brock, Asbjørn M Drewes, Birgitte Brock, Janusiya A Muthulingam, Tine M Hansen, Niels Ejskjaer, Jens B Frøkjær

Published in

Diabetes. Aug 11, 2026. Epub Aug 11, 2026.

Abstract

Accelerated brain aging has been reported in diabetes, but its links with diabetic peripheral neuropathy (DPN) and neuropathic pain remain unclear. We explored brain age gap (BAG) in type 1 diabetes to determine if it differs across neuropathic phenotypes, relates to clinical characteristics including DPN measures, and shows distinct regional patterns. Diabetes participants had 3.5 years of BAG, rising to 6-7 years in those with DPN. Diabetes duration was the main driver of BAG, whereas DPN had limited impact and neuropathic pain no clear contribution. BAG was widespread across the brain. Accelerated brain aging appears to affect people with diabetes regardless of neuropathic complications.

PMID:
42579533
Bibliographic data and abstract were imported from PubMed on 12 Aug 2026.

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